[2] The river is crossed by the Sozh Floating Bridge at Karma and an elegant steel arch at Gomel, which is featured on a Rbls 300 national stamp.

[2][7] Important historical towns on the banks of the main river and its tributaries are: Krychaw, Cherykaw, Slawharad, Gomel and Vietka.

It flows further south, making the border between Khislavichsky and Shumyachsky District of Smolensk Oblast in the east, and Mogilev Region of Belarus in the west.

Several centuries ago, the East Slavic Radimichi tribal people lived in the Sozh River basin and established the Gomel town.

As a result, "a unique nature-architecture ensemble grew on the high picturesque bank of the Sozh River right in the historical center of Gomel."

Vetka, on the Sozh River, is located in an area radioactively polluted as a result of the Chernobyl disaster that occurred on 26 April 1986.

A Folk Art Museum, founded in 1987, has exhibits depicting the ancient artefacts, carved wooden entrance doors, manuscripts, traditional costumes and woven rushniki.

[8]: 209 Anthropomorphized forms of Russian myths include tales of rivalry between the Sozh, described as wild and turbulent, and the Dnieper, which is described as quiet and leisurely.

[17] Another Palaeolithic site, discovered by Konstantin Mikhailovich Polikarpovich, is located on the hill above the bank of Sozh river, in Berdizh village.

[19] Sozh River deposits that extend into Smolensk Oblast providing a supply of ground phosphate to Krychaw and Klimavichy rock plants.

[9] The Sozh is one of the two chief rivers of Mogilev in the Smolensk Oblast where the trade in the early part of the 20th century, involving primarily paper, oil, wire nails, flour, glass, and matches, was predominantly in the hands of the large Jewish population.