[5] The golden age of American animation (exemplified by the 1940s cartoons by Bob Clampett and Tex Avery) served as inspiration for the surreal and highly expressive house style of which Spümcø became well-known.

The Spümcø headquarters were located in Los Angeles, west of Paramount Studios at 5625 Melrose Avenue in a bland concrete industrial building.

Geraldine Laybourne, the president of Nickelodeon at the time, picked two of these: Ren & Stimpy and Jimmy the Idiot Boy, the former being initially rejected by three other major American television networks.

[5] Kricfalusi volunteered to give Nickelodeon executives an informative background of cartoonists using storyboards for storytelling in animated cartoons, rather than a script.

[5] Vanessa Coffey, who became the executive for The Ren & Stimpy Show, listened to Kricfalusi's lessons and background briefing of the animation industry, and was pleased to learn about how the process works.

"[5] Spümcø finished the pilot "Big House Blues" in October 1990 and it aired on August 11, 1991, premiering alongside Doug and Rugrats.

[12] Kricfalusi confirmed that the primary reason for the Nickelodeon executives' decision seemed to be due to the level of violence in Ren & Stimpy.

He specifically referred to the episode "Man's Best Friend", which features Ren beating the character George Liquor with an oar, as the probable cause for his firing.

Wray said that Kricfalusi believed that the product's quality holds more importance than meeting deadlines, and that he perceived Nickelodeon as "slowing him down".

[16] Kevin Kolde became a key figure of the company, working as a vice president and general manager, enabling Spümcø to continue producing content for over a decade after the original run of Ren & Stimpy.

[20] In 1999, The Goddamn George Liquor Program won an Annie Award for "Outstanding Achievement in an Animated Interactive Production".

After Nickelodeon fired Kricfalusi from The Ren & Stimpy Show in September 1992, he had plans to make a feature film starring the world's "manliest men".

[29] Spike TV planned to bring the show back with the final remaining episodes on August 20, 2004, but delayed the series and cancelled it in early July 2003.

The games were developed in collaboration with Sony Computer Entertainment, and released exclusively in Japan for the PlayStation 2 on December 6, 2001, and January 24, 2002, respectively.

The game's story states that Toon World is helping Spümcø "to renew interest in the medium and revive the struggling economy [of traditional cel animation]".

Doug Lawrence, a layout assistant on the show, became a key writer on Rocko's Modern Life; he would also do so for SpongeBob SquarePants.

Members who initially refused to join Games Animation, including Vincent Waller and Richard Pursel, co-founders Bob Camp and Lynne Naylor, Games Animation hires Chris Reccardi and William Wray as well as later Spümcø employees including Aaron Springer would work on SpongeBob of varying capacities; Waller serves as a showrunner on the series as of 2024.

In 2016, it was announced on Tumblr that Kricfalusi and former Cartoon Network storyboard artist Gabe Del Valle were starting a new studio based in the Los Angeles area and were seeking new employees.

[40] The studio's only project was an animated short for Adult Swim, which advertised the then-upcoming UFC 200 match on July 9, 2016, produced prior to the announcement of forming the company.

Many of Kricfalusi's fans were left wondering if the people involved in the project were unable to get further funding or a distribution agreement or that they could not obtain the proper licensing to use clips.

[citation needed] On February 1, 2013, Sick Little Monkeys: The Unauthorized Ren and Stimpy Story was published by animation historian Thad Komorowski.