SpaceX CRS-22, also known as SpX-22, was a Commercial Resupply Services (CRS) mission to the International Space Station (ISS) that launched at 17:29:15 UTC on 3 June 2021.

[4] The new Cargo Dragon capsules under the NASA CRS Phase 2 contract splash down under parachutes in the Gulf of Mexico rather than the previous recovery zone in the Pacific Ocean west of Baja California under the NASA CRS Phase 1 contract.

[9] Additional hardware carried internally includes: The new experiments arriving at the orbiting laboratory on the SpaceX CRS-22 mission supports science from human health to high-powered computing, and utilizes the space station as a proving ground for new technologies.

[16] These include: ELaNa 36: One CubeSat is scheduled for deployment on this mission:[17] Nanoracks CubeSat deployments: UNOOSA / JAXA KiboCUBE program:[19] Beginning with returning capsules or lifting bodies under the CRS-2 contract, NASA reports major hardware (failed or expended hardware for diagnostic assessment, refurbishment, repair, or no longer needed) returning from the International Space Station.

The SpaceX CRS-22 mission ends on 10 July 2021, this is a two-day delay from the original undocking target of 6 July 2021 as a result of Tropical Storm/Hurricane Elsa causing weather concerns at the splashdown zones,[23] with re-entry into atmosphere of Earth and splash down in the Gulf of Mexico near the western coast of Florida with 2,404 kg (5,300 lb) of return cargo.