With its return to Earth the evening of 9 November 2021, the mission set a record for the longest spaceflight by a U.S. crewed spacecraft, 199 days.

[6] On 28 July 2020, JAXA, ESA and NASA confirmed their astronaut assignments aboard this mission.

[12][13] All crew members were veteran astronauts, though this was Megan McArthur's first visit to the ISS (as her first spaceflight was STS-125, a mission to the Hubble Space Telescope).

McArthur used the same seat on the Crew Dragon Endeavour which her husband, Bob Behnken, used on the Demo-2 mission.

[21] Due to weather delays and a minor health problem with one of the SpaceX Crew-3 astronauts,[23] NASA decided to bring home the Crew-2 astronauts from the ISS before launching Crew-3, thus being the first Crew Dragon indirect handover of space station crews.