Its initial iteration included some of the earliest work of industry notables Steve Ditko, Dick Giordano, and Tony Tallarico, and at least one story by EC Comics mainstay Bernard Krigstein.

The following two issues were cover-billed Space Adventures Presents The Blue Beetle, and featured reprints of the defunct publisher Fox Comics' superhero, from 1939.

Issues #15-18 (March-Sept. 1955) carried the rubric Space Adventures Presents Rocky Jones, and featured that children's television character in licensed TV spin-off stories.

Issues #19 and #21 reverted to Space Adventures, interspersed with another licensed tie-in, Space Adventures Presents First Trip to the Moon — a retitled reprint of writer Otto Binder, penciler Dick Rockwell and inker Sam Burlockoff's adaptation of the movie Destination Moon, from Fawcett Comics' 1950 one-shot of that name.

Writer Joe Gill and artist Ditko introduced the space-age superhero Captain Atom in a nine-page story in issue #33 (March 1960).

This featured early work by such later notables as writer Denny O'Neil (using the pseudonym Sergius O'Shaughnessy), and artists Jim Aparo and Pat Boyette.