After achieving great success in Italy with the Italian version of Elton John's "Circle of Life" ("Il cerchio della vita"), featured in the Italian soundtrack of the Disney film The Lion King, she took part in the Sanremo Music Festival 1995, ranking 3rd with the song "Gente come noi".

From that year onwards, Spagna released many successful albums sung in Italian (including hit singles such as "Siamo in due", "E io penso a te", "Lupi solitari", "Indivisibili", "Dov'eri", "Il bello della vita-World Cup Song", "Con il tuo nome") until 2003, when she left Sony Music in order to sing in English again.

Spagna's albums and singles have sold a total of over 15 million copies worldwide, for which she has been awarded the "Disco d'oro alla carriera" (gold certification for the career) by the Italian Federation of the Music Industry (FIMI) in 2006.

In February 2006, she took part in the Sanremo Festival again, with the song "Noi non possiamo cambiare", and in May 2006 ranked third in the Italian reality television program, Music Farm.

[3] In February 2009, she released the EP Lola & Angiolina Project, in collaboration with the Italian singer Loredana Bertè.

In 2012, Spagna released the English-language album Four, featuring Brian Auger, Eumir Deodato, Dominic Miller, Lou Marini, Gregg Kofi Brown, Fabrizio Bosso and Ronnie Jones.