After years spent in the Italian alternative market, they became more widely known in 2005 thanks to their participation in the Sanremo Music Festival 2005 with the song "Mentre Tutto Scorre".

The collaboration between them spawned a brand new track, "Scusa Se Non Piango", and three remixes of previous songs: "Es-Senza", "Evidentemente" and "Come Sempre".

The 2004 version of "Come Sempre" was released as a single with better success of the previous ones, and was even chosen as the soundtrack to celebrate the 50th birthday of the Italian TV network RAI.

Negramaro performed the song "Mentre Tutto Scorre" at the Sanremo Music Festival 2005, but were eliminated at the first turn.

Thanks to hit singles, good performances and critics, their album Mentre Tutto Scorre gained a lot of success, being certified 6× platinum in Italy.

[2] The album was promoted by the collaboration "Basta così" with Elisa, which peaked at number seven on the Italian Singles Chart and was certified double platinum by FIMI.

[6][7] Throughout 2016, the group had split for two months due to some artistic and personal discrepancies between frontman Giuliano Sangiorgi and keyboardist and programmer Andrea Mariano.

[12] Through 2018 the band published three singles from the album, "La prima volta", "Amore che torni" and "Per uno come me", all certified platinum by FIMI.

[18] In the same year they released two more singles: in April "Luna piena" and "Marziani",[19][20] which anticipated the album Free Love, published on 22 November 2024.