With the construction of the fortress in the middle of the 17th century, the Spandauer Gate was moved a little to the east in the area around today's Hackescher Market, but the name was retained.

On the occasion of her marriage in 1668, Dorothea of Schleswig-Holstein-Sonderburg-Glücksburg received property in the area of the Spandauer and the Tiergarten, which later became Dorotheenstadt, as a gift.

Around 1700, on the Spandauer Heerweg (Historic Roman road), in front of Monbijou Palace, was rebuilt as Oranienburger St main avenue through the neighborhood.

The New Synagogue - Centrum Judaicum, was restored and opened in 1995, is located at Oranienburger Strasse 28–30, a center dedicated to the care and preservation of Jewish culture.

[7][8] The Anne Frank Center and the Museum of Otto Weidt's Workshop for the Blind are located near Hackescher Market at Rosenthaler Straße 39.

[12] The ruins of the former Passage Department Store on Oranienburger St were occupied by artists in 1992 and made a name for themselves as the Kunsthaus Tacheles.

In the Hackesche Höfe complex, at Rosenthaler Straße 40/41, there is the Theater Chamäleon which was founded in 1991 and shows changing programs.

[18] The Sophiensæle is another location for theater and dance in the Handwerkervereinshaus (Craftsman's Association) building, built in 1904–1905 by the architects Joseph Fraenkel and Theodor Kampfmeyer.

[19] The Clärchens Ballhaus, is a historic ballroom, dancehall, and restaurant which has been operating continuously for over 100 years, located on Auguststrasse.

[20] Between 1703 and 1706 King Friedrich I had the court architect Eosander von Göthe built a small pleasure palace in the late Baroque style on the north bank of the Spree beyond the Spandauer Gate.

[22] In 1859, the building of the Cathedral Candidate Foundation (in German, Domkandidatenstift), built according to plans by Stüler, was inaugurated at Oranienburger Strasse 76a.

[23] The St. George's Church, built according to plans by architect Julius Raschdorff in 1885, was inaugurated on the grounds of Monbijou Castle.

[26] Between 2013 until 2015, some 319 apartments in six prefabricated complexes in the Spandauer Vorstadt district that have been renovated by the Wohnungsbaugesellschaft (or Housing Association), Berlin-Mitte (WBM).

[26] Around the neighborhood are Stolpersteine (stumbling stones) in front of many buildings and memorial sights, this was from a project from the 1990s where a brass plate inscribed with the name and life dates of victims of Nazi murder or persecution, most of which were Jewish people.