She served briefly in the Mediterranean, where she captured two French privateers and several merchant vessels before the Royal Navy sold her at Malta in 1802, after the Treaty of Amiens ended the war with France.

During the Battle of the Nile, she took refuge under the forts of Abukir, and formed up with Rear-admiral Villeneuve's squadron, which comprised the two 74-gun Guillaume Tell and Généreux, and the frigates Diane and Justice.

[7] On 8 May 1799, Salamine encountered the xebec HMS Fortune, under the command of Lieutenant Lewis Davis, and her consort Dame de Grace.

This was the Vierge de Graces, which Commodore Sir Sidney Smith in Tigre captured when he took a flotilla of seven vessels at Acre on 18 March 1799.

[14] Sixty miles off Toulon, on 17 June, Perrée's division met Lord Keith's fleet, who dispatched a force consisting of three 74-gun ships and two frigates, all under Captain John Markham, to intercept it.

[17] On 9 April Salamine captured a Genoese settee that was sailing from Languedoc to Nolle [sic] with a cargo of wine.

[18]) Then two days later Salamine captured the French tartan, the Madona de Montenero, which was carrying salt fish, sugar, and similar cargo.

[20][Note 2] About six weeks later, on 14 June, Salamine and Cameleon captured the Genoese brig Anima Purgatoria, which was sailing from Bastia to Saleolight [sic].

[23] A little more than three weeks later, on 21 January 1801, Caroline and Salamine captured another French privateer, or judging from her crew size, more properly, a letter of marque.