Mexicano (or Mejicano) was a 112-gun three-decker ship of the line built at Havanna for the Spanish Navy in 1786 to plans by Romero Landa.

Although she was a formidable part of the Spanish battlefleet throughout these conflicts, the only major action Mexicano participated in was the Battle of Cape St Vincent in 1797.

Mexicano was constructed at Havanna, built over eleven months in 1785 at a cost of 328,000 pesos, most of which was supplied by the Cabildo of New Spain, known as Mexico and from where the ship took its name.

The maiden voyage of Mexicano was made from Havanna to Ferrol with a light armament of 80 guns under Captain Miguel Felix Goycoechea, who reported that the ship sailed smoothly and with endurance.

The Spanish fleet was defeated and four ships were lost, although Mexicano survived the battle with losses of 25 killed, including Captain Francisco de Herrara and 46 seriously wounded.