San Antonio was a 74-gun, two-decked, third-rate ship of the line built for the Spanish Navy and launched in Cartagena in 1785.

The San Antonio was handed over in May 1801 to become the French ship Saint Antoine under Commodore Julien Le Ray, though some Spanish seamen remained aboard.

Taking part in the Second Battle of Algeciras during the night of 12–13 July 1801, she was pursued by HMS Superb, Captain Keats, the combined French and Spanish crew engaging the British vessel as it approached.

Saint Antoine was commissioned by the Royal Navy in 1801 as the San Antonio and sailed under Captain Dundas[4] to Portsmouth.

There she was laid up for repairs and eventually commissioned as a Prison ship in October 1807, and later as a powder magazine from May to September 1814.