San Francisco de Asis was a 74-gun ship of the line of the Spanish Navy launched in 1767 from the royal shipyard in Guarnizo, Cantabria.

On January 25, 1797, San Francisco de Asis, under the command of Captain Alonso de Torres y Guerra, was on patrol off the coast of Cádiz for the protection of Spanish ships arriving with goods from America when it was attacked by a British Royal Navy squadron consisting of three frigates and a corvette.

[1][2] She was repaired and on February 14 of that same year took part in the Spanish defeat at the Battle of Cape St. Vincent.

In 1805, San Francisco de Asis participated in the Battle of Trafalgar under the command of Captain Luis Antonio Flores.

After the battle and after repairing some of the damage inflicted to San Francisco de Asis, she went out again with several Spanish and French ships to try to recapture warships captured by the British, managing to recapture the Santa Ana and Neptuno.