Spantekow is a municipality in the Vorpommern-Greifswald district, in Mecklenburg-Vorpommern, Germany.

It comprises the villages Dennin, Drewelow, Fasanenhof, Janow, Japenzin, Neuendorf B, Rehberg, Rebelow and Spantekow.

Since the Middle Ages, Spantekow is a local administrative center and the site of a fortress.

Though Spantekow castle was largely destroyed in a Brandenburgian attack in 1677, it remained a residence of the local nobility until 1945.

Today, the village is seat of the Amt Anklam-Land.