[1][2][3][4] Is located in the architectonic complex of the old Papandrea House, an Art Deco-style villa, adapted for the new function after a long and detailed philological restoration.

This architectural complex contains an internal part for exhibitions and an external one, thanks to the presence of a courtyard already used for the placing of sculptures by Sardinian artists.

[5][6][7][8][9] On one of its floors and in the internal courtyard it hosts, from 7 July 2021, a permanent exhibition on the most important Sardinian sculptors of the twentieth century.

The permanent collection, inaugurated on 7 July 2021,[10][11][12][13] is dedicated to 20th century Sardinian sculpture, and includes works by Francesco Ciusa, Maria Lai, Salvatore Fancello, Costantino Nivola, Eugenio Tavolara, Pinuccio Sciola and Gavino Tilocca.

[14] Spazio Ilisso hosts the digital archives of Applied Art and Historical Photography, which collect photographs, films and documentaries on Sardinia with contributions from many photographers such as Marianne Sin-Pfältzer, Max Leopold Wagner, Raffaele Ciceri, Antonio Ballero.