U.S. Route 401 Business (US 401 Bus) was established in 1960 as a renumbering of US 401A through downtown Laurinburg, it has remained unchanged since.

U.S. Route 401 Business (US 401 Bus) was established in late 1960s from a renumbering of US 401, this business loop goes through Fayetteville via Raeford Road, Robeson Street, Martin Luther King Jr Freeway, and Ramsey Street.

U.S. Route 401 originally passed through the town until the bypass was completed in 2015.

was a 3.4-mile (5.5 km) business route of US 401 that traveled through Bennettsville via Main Street and Tyson Avenue.

[citation needed] U.S. Route 401 Alternate (US 401A) was established in 1957, when US 401 was re-established, it replaced US 15A alignment through downtown Laurinburg, via Main Street.