It traveled due west along Missouri Route 242, briefly south along Osage Beach Parkway, and west along Bagnell Dam Boulevard to get to downtown Lake Ozark.

[5] Then, in 1968, US 54 was rerouted onto a newly-opened bypass; Missouri Route 354 briefly took the place of US 54's old alignment.

A three-mile (4.8 km) business loop exists in Bowling Green, Missouri.

A three-mile business loop exists in Louisiana, Missouri.

[17] In 1959, US 54 was rerouted onto a bypass (now part of Interstate 57) which, as a result, created US 54 City.

[18] Originally, the freeway abruptly stopped at North Street which caused US 54 to travel west to its city route.

[15] It remained like that until 1962 when a freeway connection between US 54 Business and North Avenue was made.

[19] In 1969, US 54 supplanted its business route as the bypass was extended on both ends.

[16] Three years later, in 1972, US 54 was significantly truncated, removing a section of US 54 between Griggsville and Chicago.