The route runs along former sections of the main route along Muskogee Avenue beginning at the western terminus of US 62/OK 82's overlap with OK 51, then runs north into downtown Tahlequah, where it turns right running east along East Downing Street until reaching its terminus at the east end of the US 62/OK 82 overlap.

[6] It was truncated to Prairie Grove Battlefield State Park in February 2023, with the remainder becoming a city street.

The highway crossed the Arkansas and Missouri Railroad tracks before an intersection with AR 12 (Locust Street).

The two highways form a concurrency southbound, together entering Historic Downtown Rogers.

The route runs east as Oak View Drive, passing the industrial park area of the city.

[14] State maintenance ends at a fork in the road with A. L. Carter Street to the north and Oak View Drive continuing south.

The route runs north into downtown Pyatt, connecting the residential area with Highway 62.

[19] The route passes the Pyatt School Building and crosses Crooked Creek on the National Register of Historic Places (NRHP) listed Crooked Creek Bridge.

[20] State maintenance ends at County Route 321 (CR 321), locally named Bradford Street.

The route runs due east as Old Main Street through downtown Yellville, connecting the residential area with Highway 62.

[21] The route passes the Yellville Public Library, the Layton Building, and the Marion County Courthouse, with the last two properties being National Register of Historic Places (NRHP) listed.

The route runs east as Ruthven Street on the Cotter Bridge over the White River.

The route passes the Old Cotter High School Gymnasium listed on the National Register of Historic Places (NRHP).

[20][26] Continuing northeast, the route nears the Cotter Water Tower before terminating at US 62/US 412.

Further northeast the route forms a concurrency with Highway 5/Highway 201, becoming Main Street, and passing the Mountain Home Commercial Historic District and Baxter County Courthouse.

US 62B runs east along Church Street to the town square, where it turns south along Highway 9.

US 62T, a four-lane highway, begins at US 62 (Atlantic Boulevard NE/State Street) in Stark County.

Exit ramps provide access from US 62T to Beeson St NE, and then the highway merges onto State Route 225 (SR 225) and ends.

Although the US 62T designation is unsigned, signs on the road read "To West US 62 / To State Route 225 North".

The entire route is built to freeway standards with a speed limit of 60 miles per hour (97 km/h).

U.S. Route 62 Business follows Pine Avenue through downtown Niagara Falls, New York, spanning 2.12 miles (3.41 km) between NY 104 at its western terminus and US 62 at its eastern extent.

NY 18 was truncated to Lewiston, a village north of the city, in the early 1960s, making US 62 the sole occupant of Pine Avenue.

US 62 was shifted onto its current alignment through the city later in the decade, allowing Pine Avenue to become New York State Route 62A in the 1970s.