The most well-known mixture used for recreational drug use is that of cocaine and heroin; however, amphetamines can also be mixed with morphine and/or fentanyl.
[12] Pink cocaine or "tusi" usually includes an unknown mix of uppers and downers and is sometimes called a speedball.
[16][17][18] It is a widespread misconception that taking downers will reduce the risk of adverse cardiac effects from stimulants, or vice versa.
The variations in heart rate and contraction caused by taking the mix of uppers/downers can lead to stroke or death even in young, healthy persons.
[14] In 1996, Steven Adler had a stroke after taking a speedball, leaving him with a permanent speech impediment.