A native of Austin, Texas, Drango attended Cedar Park High School, where he was an All-State offensive lineman.

As senior, he registered 144 knockdowns while not allowing a sack, helping Cedar Park to a 13–1 record and UIL quarterfinals, where they lost 21–20 to Michael Brewer's Austin Lake Travis.

Midway through his sophomore season, Drango had back surgery for a ruptured disk, but Baylor athletic trainer Jacob Puente helped him recover so he could play football once again.

61 scouts and representatives, including Pittsburgh Steelers head coach Mike Tomlin and Houston Texans head coach Bill O'Brien, from all 32 NFL teams came to watch Drango, Corey Coleman, Shawn Oakman, Xavien Howard, Andrew Billings, and 11 other prospects workout.

[10] Although Drango was a top 10 tackle at Baylor each of the past two seasons, almost all analysts pegged him as an offensive guard in the NFL.

On October 22, 2017, Browns starting left tackle Joe Thomas went down with a torn triceps injury after he had played 10,363 consecutive offensive snaps.

On October 23, 2017, Browns head coach Hue Jackson stated that Drango would start at left tackle in place of Thomas.