Spermacoce neoterminalis, the Everglades Key false buttonweed, is a species of plant in the Rubiaceae.

It is endemic to southern Florida, from the Everglades as far north as Lake Okeechobee.

[1][2][3][4][5] Spermacoce neoterminalis is a perennial herb with a woody root.

Stems are up to 40 cm tall, generally not branching above the ground.

Flowers are small, white, clustered in terminal and axillary glomerules.