[1] He was the author of a number of works on Byzantine and Greek-Turkish relations, including his seminal The Decline of Medieval Hellenism in Asia Minor (1971) and The Mechanism of Catastrophe (2005).

He received his Masters of Arts from Harvard University two years later and his Ph.D. from the same school in 1956.

[2] Vryonis carried out his post-doctoral research at Dumbarton Oaks before joining the history faculty at the University of California, Los Angeles in the mid-1960s, where he served as the director of the G. E. von Grunebaum Center for Near Eastern Studies.

In 1987 he was tapped to head the Alexander S. Onassis for Hellenic Studies at New York University.

He was the AHIF Senior Fellow for Hellenism and for Greek and Turkish Studies.