The inner city can be reached by buses operated by Busverkehr Rhein-Neckar (BRN) in five minutes.

On 10 December 1873, it became the terminus of the Heidelberg–Speyer line, which was closed in 1945 after the destruction of the bridge over the Rhine.

Between 1905 and 1956 the Neustadt–Speyer Local Railway ran between Speyer and Neustadt an der Weinstrasse.

On 16 December 1944 it was the target of an air attack that destroyed the station building and it was rebuilt in 1953.

Temporary buildings were built, which were then replaced in the style of the time.