Two years later, however, the plans were dropped for economic and military reasons by the other states the railway would have crossed: the Grand Duchies of Baden, Hesse and the Kingdom of Prussia.

The private company constructing and later operating it was called the Hessian Ludwig Railway (German: Hessische Ludwigsbahn).

The Worms council pressed for a central location near the Rhine port, near the present Rheintorplatz, but on 21 September 1852 the Hessian Ludwig Railway chose a site near the cemetery, now Albert-Schulte Park.

After an initial underestimation of freight traffic, extra facilities were built at Worms station in the following years: a loading dock, a goods shed and a marshalling yard.

Now there were regular freight trains conveying sugar beet, grain, coal and much else to the factories, mills and ports in Worms.

The approximately 110 metre-long front side of the station building on Bahnhofstraße was dominated by its entrance hall, which was next to baggage handling facilities and administration offices.

Approximately 35 years later, at the end of the Second World War, great damage had been done to Worms station: as a result of an air raid on 18 March 1945, all tracks and the interlockings as well as the operations yard, with its rectangular shed, roundhouse and workshops, and the freight yard were completely destroyed.