[1] Spherocytes are found in immunologically-mediated hemolytic anemias and in hereditary spherocytosis, but the former would have a positive direct Coombs test and the latter would not.

However, they have a high osmotic fragility—when placed into water, they are more likely to burst than normal red blood cells.

[citation needed] In short, spherocytosis has an attribute of decreased cell deformability.

[citation needed] Treatment may vary depending on the cause of the condition.

[5] Current management focuses on interventions that limit the severity of the disease.