ASCII Media Works has also published nine volumes of a spin-off light novel series titled Wolf and Parchment since September 2016.

[2][3] A second OVA was released in April 2009 as a prequel to the second anime season Spice and Wolf II, which aired 12 episodes between July and September 2009.

Two visual novels based on the series for the Nintendo DS were released by ASCII Media Works in June 2008 and September 2009.

[6] His main goal in life is to gather enough money to start his own shop, and he already has been traveling for seven years while gaining experience in the trade.

One night when stopped at the town of Pasloe, he finds in his wagon a beautiful wolf-deity named Holo who is over 600 years old.

She is especially hurt at their forgetting of the promise made between her and a farmer when she arrived in the village and their criticism of her as a "fickle god" for needing to replenish the soil with smaller harvests.

Because of these changes, she wants to go back to her homeland in the north called Yoitsu; she believes the people have already forsaken her and that she has kept her promise to maintain the good harvests.

As they travel, her wisdom helps increase his profits, but at the same time, her true nature draws unwanted attention from the Church.

Spice and Wolf began as a light novel series written by Isuna Hasekura, with illustrations by Jū Ayakura.

[16] In celebration of the series' 10th anniversary, Hasekura began writing a sequel in the 49th volume of Dengeki Bunko Magazine, released on April 9, 2016.

[25] The show contains eight corners, or parts to each broadcast which includes news about the series, comments and submissions from listeners, and a radio drama.

[28] The series is directed by Takeo Takahashi, written by Naruhisa Arakawa, and character designs are provided by Kazuya Kuroda.

[33] A second season of the anime titled Spice and Wolf II aired twelve episodes in Japan between July 9 and September 24, 2009.

[35] Another OVA, animated by Brain's Base and Marvy Jack, was released bundled with a picture book entitled Spice and Wolf: Wolf and Gold Wheat (「狼と香辛料」狼と金の麦穂, Ōkami to Kōshinryō Ōkami to Kin no Mugiho) written and illustrated by the same creators of the light novels and was released by ASCII Media Works on April 30, 2009 under their Dengeki Bunko Visual Novel imprint.

[40] It was later confirmed to be a remake, titled Spice and Wolf: Merchant Meets the Wise Wolf, produced by Passione and directed by Hijiri Sanpei, with Takahashi returning as chief director, Kevin Penkin composing the music, and both Fukuyama and Koshimizu returning to reprise their roles as Lawrence and Holo respectively.

[49] A dating and business simulation visual novel based on the series, Spice and Wolf: Holo's and My One Year,[h] was developed by ASCII Media Works for the Nintendo DS, and was released on June 26, 2008 in Japan.

[50][51] It never had an official Western release, but received a fan translation into English by AGT Team on February 20, 2021 under the localized title Spice and Wolf: My Year With Holo.

In exchange for cheaply obtaining Holo's wagon, he promises to help her find her hometown before the year's end by using his merchant skills to purchase information.

[50][54] A sequel, also by ASCII Media Works for Nintendo DS, was released on September 17, 2009 in Japan, titled Spice and Wolf: The Wind that Spans the Sea.

[56] A virtual reality adventure game titled Spice and Wolf VR[j] and made by Spicy Tails, a dōjin group founded by Isuna Hasekura, was released on June 3, 2019 for Microsoft Windows supporting the Oculus Rift and HTC Vive VR headsets as well as the standalone Oculus Go headset.