From fifth grade on, he was designated head chorister for all the student chanters who sang in the church.”[3] In 1902 Melikyan graduated from the seminary and was ordained a deacon.

Komitas advised him to concentrate on ancient and modern music history, cultivate his voice, and deepen his knowledge of the choral art.

Fortunately, in 1931 Melikyan published the copy he had made, «Ազգագրական ժողովածու» (Ethnographic collection), thus saving a national treasure.

[4] Upon his return to Armenia in 1908, Spiridon Melikyan decided to dedicate himself exclusively to music, left the church and renounced his order of deaconship.

In 1917, he founded and directed the Armenian Choral Society, he lectured widely and authored textbooks on singing, elevating the musical sophistication of the community.

With the establishment of Soviet Armenia, Melikyan moved to Yerevan and began teaching in local music schools.

[6] Melikyan's own compositions include «Ախթամար» (Akhtamar), a ballad for orchestra and chorus, several arrangements of folk songs for solo voice and choir, some having a permanent place in the repertoire.