[5][3] Finally, Spironucleus muris is found to cause illnesses of the digestive system in mice, rats, and hamsters.

[6][3] The genome of Spironucleus has been studied to exhibit the role of lateral gene transfer from prokaryotes in allowing for anaerobic metabolic processes in diplomonads.

[7] The different species of Spironucleus can be found in a variety of animal hosts, including fish, birds, and mice.

Spironucleus vortens species is often found in freshwater angelfish, where it affects the gastrointestinal tract and may cause head and lateral line erosion.

[4][3] Pathogenesis of Spironucleus can be promoted by stressful environmental conditions, including poor water quality, malnutrition, overcrowding, and fluctuating temperatures.

The colonization and division of this species in the intestinal tract can cause small ulcerative lesions and other accompanying physical digestive illnesses.

Additionally, Whary et al. (2015) lists some physical symptoms of an infected mouse include poor hair coat, sluggish behaviour, and weight loss.

Like other Spironucleus species, transmission occurs through the faecal or oral route to infect the intestinal tract and potentially cause lethal illnesses.