The club competes in the BNXT League, the highest tier of basketball in Belgium.

Established in 1989, the team is named after the long-running Belgian comics magazine Spirou, the publisher of which, Dupuis, is based in Marcinelle, Charleroi.

In the 2010–11 season, Spirou made its debut in the Euroleague, the highest continental league of Europe.

On July 29, 2014, Jacques Stas became the new head coach of the club while his predecessor Giovanni Bozzi replaced him as team president.

[2] Partly due to sponsorship reasons, the club has known several names: Note: Flags indicate national team eligibility at FIBA-sanctioned events.