Spittelmarkt is a Berlin U-Bahn station on line U2, located in Mitte at the eastern end of Leipziger Straße.

The station was opened on 1 October 1908, and was then the terminus of Berlin's second U-Bahn line, connecting it with Potsdamer Platz on the initial Stammstrecke route.

It is named after the Spittelmarkt square, former site of the Saint Gertrude hospital established about 1400.

The name Spittelmarkt is formed from a contraction of "hospital" (as also in Spitalfields, London) and the German word for "market".

The station, designed by Alfred Grenander, was lavishly erected right beneath the banks of the Spree river, with daylight windows above the water's surface.