Splice is a 2009 science fiction horror film directed by Vincenzo Natali and starring Adrien Brody, Sarah Polley, and Delphine Chanéac.

The story concerns experiments in genetic engineering being done by a young scientific couple, who attempt to introduce human DNA into their work of splicing animal genes resulting in the creation of a human–animal hybrid.

Genetic engineers Clive Nicoli and Elsa Kast hope to achieve fame by splicing animal DNA to create hybrids for medical use at the company N.E.R.D.

Their employers Joan Chorot and William Barlow forbid this and order them to focus on identifying and extracting proteins from Fred and Ginger for drug production.

William Barlow discovers human DNA in Dren's protein samples and arrives at the barn with Gavin, who revealed the location.

In an office tower, Joan tells Elsa that Dren's body contained numerous biochemical compounds, for which the company is filing patents.

The website's consensus reads: "It doesn't take its terrific premise quite as far as it should, but Splice is a smart, well-acted treat for horror fans.

"[19] Metacritic, which uses a weighted average, assigned the film a score of 66 out of 100, based on 35 critics, indicating "generally favorable" reviews.

[21] Manohla Dargis of The New York Times wrote that Natali "hasn't reinvented the horror genre" but "has done the next best thing with an intelligent movie that, in between its small boos and an occasional hair-raising jolt, explores chewy issues like bioethics, abortion, corporate-sponsored science, commitment problems between lovers and even Freudian-worthy family dynamics.

"[22] Andrew O'Hehir from Salon said "Dark, sleek, funny and creepily infectious, the genetic-engineering horror-comedy Splice is a dynamic comeback vehicle for Canadian genre director Vincenzo Natali, who made a splash a few years ago with Cube.

"[23] Lisa Schwarzbaum from Entertainment Weekly gave the film an A− and stated, "The outstanding creature effects by Howard Berger only get more astonishing as Splice splits into an eerie horror picture, then divides again into something out of Rosemary's Baby.

[25] Comparing the film to David Cronenberg's The Brood, Peter Travers from Rolling Stone said, "Played as a child by Abigail Chu and as an adult by Delphine Chanéac, Dren morphs into a special-effects miracle, sexy and scary in equal doses."

[28] Splice won the 2011 Telefilm Golden Box Office Award, CAD$40,000, for being the highest-grossing Canadian feature film in English in 2010.