The title in English translates to Shoot and Swallow, referring to drugs and sexual intercourse.

[1] It was highly controversial from the start due to numerous drugs and sexual kinks that were tried out on television, often with participation of the hosts.

[2] In the show, discussions about sex and drugs take place with weekly guests.

In 2016 the creators of Spuiten en Slikken made the educational YouTube show Drugslab, wherein hosts try out drugs of all kinds with the aim of promoting responsible use of them.

[3] The channel quickly became popular outside the Netherlands as well, with their videos on cocaine, DMT and MDMA (ecstasy), LSD and ketamine amassing millions of views.