Spurstow appears as "Spuretone" in the Domesday Book of 1086; it was then held by Robert FitzHugh, and around 180 acres had been cleared for agricultural use.

[2][6] A silver-gilt crucifix designed to be worn on a chain, dating from the late 14th to early 15th century, was found in the civil parish in 2000.

[2][5] The spa still existed in the mid-19th century, when it appeared in the Topographical Dictionary of England (1848) by Samuel Lewis, who wrote "A mineral spring called Spurstow Spa was formerly much frequented, and baths were erected by Sir Thomas Mostyn, for the accommodation of visiters; but the waters are not at present in repute.

[11] From 1974 the civil parish was served by Crewe and Nantwich Borough Council, which was succeeded on 1 April 2009 by the unitary authority of Cheshire East.

[25] All that is left of the demolished Lower Spurstow Hall are its grade-II-listed red sandstone gate piers, dating from the late 17th century, which are topped by pineapple-shaped finials.

[8] Two grade-II-listed buildings were erected by Hungerford Crewe in the early 1870s; the former Spurstow School was designed in the Gothic Revival style by Thomas Bower and is built in red and blue brick with the tiles forming red and blue stripes;[8][10] and Spurstow Smithy is a red-brick building with cast-iron lattice windows bearing the Crewe emblem.

[30] As of 2016, there are no schools within the civil parish, though the 19th-century Spurstow schoolhouse survives as a grade II listed private house.