[3] In contrast to squalene, due to the complete saturation of squalane, it is not subject to auto-oxidation.

This fact, coupled with its lower costs and desirable physical properties, led to its use as an emollient and moisturizer in cosmetics.

[4] Squalene was traditionally sourced from the livers of sharks, with approximately 3000 required to produce one ton of squalane.

[5] Due to environmental concerns, other sources such as olive oil, rice and sugar cane have been commercialized, and as of 2014 have been supplying about 40% of the industry total.

[8][9] Squalane has low acute toxicity and is not a significant human skin irritant or sensitizer.