Squamous metaplasia

Common sites for squamous metaplasia include the bladder and cervix.

Smokers often exhibit squamous metaplasia in the linings of their airways.

These changes don't signify a specific disease, but rather usually represent the body's response to stress or irritation.

[1] In regard to the cervix, squamous metaplasia can sometimes be found in the endocervix, as it is composed of simple columnar epithelium, whereas the ectocervix is composed of stratified squamous non-keratinized epithelium.

[2] Squamous metaplasia may be seen in the context of benign lesions (e.g., atypical polypoid adenomyoma), chronic irritation, or cancer (e.g., endometrioid endometrial carcinoma), as well as pleomorphic adenoma.

Micrograph showing squamous metaplasia (centre of image) in an atypical polypoid adenomyoma . H&E stain