The comic depicts attempts by its title character, the anthropomorphic Squeak the Mouse, to outwit a cat who is chasing him.

Each issue features a zombie plotline and a pornographic section depicting one of the main characters in an orgy with several funny animal women.

[3] Although the style of the drawing is typical of children comics, Squeak indulges in graphic violent, gore, splatter and pornographic scenes.

[4] The first issue of the series is written from the perspective of the cat, who is aggravated by Squeak the Mouse, and ultimately murders the title character.

The stories were later collected in an eponymous volume in 1984 by Éditions Albin Michel and it was initially intended to be an ended series.

It had a sequel (Squeak the Mouse 2) published in 1992 also by Éditions Albin Michel and Sefam, Paris.

[6] On August 1, 1985, New York harbor officials confiscated the comic publication on the grounds that it was pornographic, but a court later overturned that decision.

"[8] The comics are considered to be an apparent inspiration for Matt Groening's The Itchy & Scratchy Show.