[5][6] Her first acting assignment was Balikar Prem, a Bengali TV series directed by Dulal Lahiri.

[7] She rose to prominence for her role as Nabanita in the 1996 Bengali TV series Trishna directed by Anindya Sarkar.

[8] After she appeared in a host of films, her breakthrough role came with Basu Chatterjee's Hothat Brishti (1998) which was a major success at the box office.

[9] Despite the success of the film, Mitra never attained any significant elevation in her career which she claimed to be an undesirable consequence of Nepotism in Bengali cinema.

[11] In 2012, she received the Zee Bangla Gourav Samman in the category of Best Supporting Actress for her role in Uro Chithi (2011).

She went to pursue masters in English literature at Calcutta University but quit it when she got a job at Taj Hotel, Kolkata.

While working at Taj Hotel, Kolkata, she was advised by one of her acquaintances to appear for an audition conducted by Teleframe, the production house of Samaresh Majumdar who had been looking for a fresh face for the female lead of his new Bengali TV series Balikar Prem.

During her working schedule in Channel 8, she met Rabiranjan Maitra who helped her bag roles in two consecutive Odia feature films.

[9] In her 2020 vlog Let's Expose Face It, she claimed that she never had any significant elevation in her career even after the huge success of Hothat Brishti (1998).

She exposed that she had to lose a number of central female roles since she never showed any interest to be the ladylove of Prosenjit Chatterjee who, then had a monopolistic foothold in Bengali film industry.

Why would I knock on doors asking for work?She garnered wider applause for her role in Pratibimba, a Bengali TV series broadcast on Alpha Bangla between 2002 and 2004.

[citation needed] In 2003, Mitra appeared, alongside Aamir Khan in a Coca-Cola advertisement directed by Pradip Sarkar.

In 2006, she came to wider attention for her role in Bappaditya Bandopadhyay's much acclaimed film Kantatar, where she essayed the character of Sudha, an illegal immigrant who moves from one man to another and from one religion to another in quest of love.

[27] She featured as Raka opposite Indraneil Sengupta in Kamaleswar Mukherjee's drama film Uro Chithi (2011).

[34] In 2015, she collaborated with Raja Dasgupta in his big screen directorial debut Choukaath, where she essayed the role of Debi who meets an accident, loses her consciousness and is taken to the hospital by an unknown passer-by.

[37] She accepted the role of Bimala in Reema Mukherjee's directorial debut Ardhangini Ek Ardhsatya (2016) based on Tagore's much celebrated novel Ghare Baire.

[57] She approached by Rashed Raha, to portray the role of Anamika Saha, a successful entrepreneur his Bangladeshi venture Kolkata Diaries.

[58] On 17 June 2020, Mitra uploaded a vlog Let's Expose Face It on her YouTube channel Aami Sreelekha claiming that she never had a significant elevation in her career even after the remarkable success of Hothat Brishti (1998) since she never reciprocated to the love proposal of Prosenjit Chatterjee who then had a monopolistic foothold in Bengali cinema.

There are good and bad people.On 23 August 2024, in the wake of Hema Committee report, Mitra levelled accusations against Indian filmmaker Ranjith.

In an interview with PTI, she alleged that she walked out of his directorial venture Paleri Manikyam: Oru Pathirakolapathakathinte Katha (2009) as he intended to seek sexual favour from her during the audition.

[64] She further added that she did not have confidence to pursue the matter any further to prosecute Ranjith for the offence attracting sections 354, and 354 B of the IPC at the time of the commission of crime as she hailed from West Bengal.

[a][67] Veena George said in this regard that Kerala Government would provide all the facilities and safety in case Mitra intended to go ahead with the allegation.

[64] National Award winning Indian filmmaker Joshy Joseph persuaded her to file an official complaint against Rajith.

[66] Certain comments from the public functionaries also were brought to my notice and the response would show that a written complaint is necessary to register a crime.

As the conduct of Sri Ranjith constitute the commission of a cognizable offence, a written complaint is not a prerequisite, as I am told, following the judgment of the Hon'ble Supreme Court.

This may be treated as a complaint and set the law in motion, as insisted by the State functionaries to initiate criminal action against an offender.On 26 August 2024, Mitra lodged an official complaint against Ranjith with the Kochi Police Commissioner claiming that the director had clutched her hand and later on attempted to spread his hand to the other parts of her body with sexual intention.

[75] Her equation with Soukarya Ghosal deteriorated when she was informed by director Aditya Vikram Sengupta that her name was not there in the credit-list of Rainbow Jelly on Netflix.