She started her career as a television host and made her film debut with a supporting role in Julai (2012).

The following year she did a small cameo in Sekhar Kammula's Life is Beautiful and was the lead actress in Dhanalakshmi Talupu Tadithey and Nara Rohit's Savitri.

[9] In 2015, Sreemukhi co-hosted the South Indian International Movie Awards (SIIMA) in Dubai.

[10] She also hosted stand up comedy show Pataas for ETV Plus, Bhale Chance Le for Star Maa, and appeared in the film Gentleman.

A reviewer from The Times of India wrote, "Sreemukhi deserves better than a film that uses a ‘good message’ as an excuse to minimise her to nothing but a glam doll.