It was established as a state university by the Andhra Pradesh legislature in 1983 to provide Higher Education in general & professional areas for women.

It is named after the goddess Sri Padmavati, the consort of Lord Venkateswara.

Prof. V.Uma, Department of Social Work, Sri Padmavati Mahila Visvavidyalayam, Tirupati was appointed as the In-charge Vice-Chancellor in 2024.

New features are courses that have a great demand in the job market such as MBA in Media Management, Integrated (five-year) course in Bio Technology, Bachelor of Physical Education and BioInformatics.

The campus of Sri Padmavati Mahila Visvavidyalayam covers 138 acres (56 hectares) in a semi-urban area at the foot of the sacred Tirumala Hills.