She debuted in 2004, playing the leading role in the film Wild Side, directed by Sébastien Lifshitz.

[1] For this role, she won the Prix Michel-Simon [fr; lb] for Best Actress.

[4][5] Michelini had auditioned for the title role of the series Louis(e) [fr], however, Claire Nebout was cast in the part.

[7] In 2019, she starred with actress Myriam Boyer in the short film Traverser la nuit, directed by Johann G.

[8] She won an Honorable Mention award for the role at the Two Riversides Film and Art Festival in Poland in 2020.