[1] In the present-day city of Vancouver, on 30 July 1863, the Reverend Ebeneezer Robson, a Methodist minister from New Westminster, held the first preaching service of any kind at Stamp's (Hastings) Mill to a group of six men.

The Reverend Robert Jamieson travelled upriver as far as Fort Langley, and established a church on Sea Island, in the river's estuary.

Subsequently, the Reverend T. G. Thompson began services in Vancouver, and a Presbyterian church was built on Oppenheimer (now Cordova) Street.

[5] A growing need led to the construction of a second and more expansive building to the west, St. Andrew's Presbyterian, opened in 1890 and located at Georgia and Richards Streets.

[17] In 1969, St. Andrew's-Wesley commissioned French stained glass artist Gabriel Loire for the east window, the inspiration drawn from Mark 16:15, "Go Ye into all the World."

[20] In contrast to the older leaded glass technique, Loire's creations were made using the more robust Dalle de verre method.

Other artists who have designed stained glass for the church include Rupert Moore, Louise Duthie, and Lutz Haufschild.

[27] Besides a seismic upgrading and receiving a new copper roof, the original plaster interiors would be restored, and a new stone floor and pews put in place.

[32] In 1986, the Moderator of the church, the Reverend Robert Smith, apologized to Indigenous people for past wrongs, a declaration that was somewhat controversial at the time.

He had a mixed legacy, being generally well regarded by the Indigenous community, and writing a Chinook-English dictionary while at the same time opposing the potlatch.

As a mark of respect and to denote the occasion, the church invited Sam George, a Skwxwú7mesh elder and residential school survivor, to give a sermon.

[28] According to CTV,[37] along with an unnamed Bowen Island community group, St Andrew's-Wesley United Church sponsored Ibrahim Ali into Canada.