The parish is multi-lingual, with Masses said in English daily, Urdu weekly, and Punjabi, Tamil and Konkani on special feasts.

In 2011, the parish is estimated to provide spiritual care to 15,000 people largely due to inter-parish migration and the construction of many housing units in the vicinity of the Church.

Every Tuesday, a large number of devotees from all over Karachi make the pilgrimage to the church to attend the special prayers to St. Anthony.

The Fete after the Patron's Feast draws large crowds and affords an opportunity to the parishioners not only to socialise, but also raises funds for the charitable undertakings of the parish.

The parish also caters to the needs of new communities and Masses are said in the newly constructed premises of the Presbytery (in Civil Lines), Stella Maris (old Clifton) and Shirin Jinnah Colony (near the Boating Basin).

The parish is also home to a number of religious communities such as the Congregation of Jesus and Mary, Sisters of the Good Shepherd and the Daughters of the Cross.

[5] The parish also fields a soccer team and participated in the Karachi Goan Association Gymkhana All-Christian football tournament on 23 November 2003 at the KGA ground.

[7] On 25 March 2012, more than 600 people gathered at the Church for a special Mass to celebrate Sister John Berchmans Conway and Fr.

Robert McCulloch receiving the country's highest civilian award - Sitara-e-Quaid-e-Azam, for their services in the fields of education, health and promoting interfaith harmony.