Named in honor of Anthony of Padua, it falls within the jurisdiction of the Diocese of Wilmington and is operated by the Oblates of St. Francis de Sales.

It is situated in Wilmington's Little Italy neighborhood, where the parish includes St. Anthony's School (adjacent to the church) and Padua Academy.

Every June, the church runs an Italian Festival, a week-long event which celebrates the Feast of Saint Anthony.

This festival features four outdoor cafes, each with their own live entertainment, and unique food selections.

[2] The Romanesque revival architectural style owes its inspiration to the Basilica di San Zeno in Verona, Italy.