Saint Bernardino of Siena Between Two Angels is a painting attributed to the Italian Renaissance artist Andrea Mantegna and his assistants, dated to 1460 and housed in the Pinacoteca di Brera of Milan.

The painting was located in the funerary chapel of marquis Ludovico III Gonzaga, dedicated to Saint Bernardino and situated in church of San Francesco in Mantua.

He holds the IHS monogram (referring to the name of Jesus) on a gold plate, which he usually displayed at the end of his sermons.

The architrave carries the inscription "Huius lingua salus hominum", meaning "His word is the safety of men".

The arch is decorated with festoons with flowers and fruit, a typical element of Mantegna's paintings in Padua, influenced by Francesco Squarcione.