First established as a general and marine cottage hospital, it moved to Queenston Street in 1870.

The hospital closed on March 24, 2013 after the new Niagara Health System St. Catharines site opened on Fourth Avenue.

Some parts of the hospital, such as the decorative arch, were preserved for reconstruction due to their historical value.

Bricks from the hospital were sold and the proceeds were donated to the Lincoln County Humane Society.

One tunnel was connected to a church; another appeared to go underneath Queenston Street, but was covered with bricks.