Shortly after St. Catharines went through another rebuilding period, but failed to see its fruits as the club ceased fielding a professional team in 2014 after the de-sanctioning of the CSL by the Canadian Soccer Association.

In 1972, the organization transferred to the Inter-City League where Roma quickly established itself as a powerhouse claiming a double in 1973, two consecutive playoff championships in 1974, and 1975.

[3] The following year the club was granted a franchise in the National Soccer League (NSL), later renamed the CNSL with the addition of the Winnipeg Fury in 1993, and changed their name to St. Catharines Roma.

Prominent players during that time period were future Canadian internationals Tomasz Radzinski, Davide Xausa, Martin Dugas, and Paul Fenwick.

The roster consisted of Canadian international Lucio Ianiero, Dino Perri, Carlo Arghittu, Shayne Campbell, Paul Moore, Chris Handsor, and Gary McGuchan.

In the finals the Wolves faced the regular season champions Toronto Italia, but failed to capture the championship after losing by a score of 11–0 on goals on aggregate.

The Wolves continued their dynasty with another double victory for the club, going undefeated the entire league season and posting the best offensive record.

In the first round of the postseason the Wolves faced Kosova Albanians, and advanced to the championship finals by winning the series 5–4 on goals on aggregate.

[24] In 1999, St. Catharines experienced several bumps in the road throughout the season as losing their top striker Carlo Arghittu to the Toronto Lynx of the USL A-League.

[25][26] Roma Wolves recovered from their mediocre season with head coach Ianiero re-signing the core members of the team, by bringing back Arghittu, Hughes, and recruiting the services of Andrew McKay, and Danny Gallagher.

The team's momentum continued throughout the Open Canada Cup tournament where history repeated itself with St. Catharines reaching the finals, and facing their rivals the Toronto Olympians.

[33] In the next round they faced regular season champions Ottawa Wizards, and avenged their Open Canada Cup loss with McGutchan providing once more the goal which resulted in a 1–0 victory for the club, and a trip to the CPSL Championship finals match.

[39][40] One notable addition to the changes were the hiring of former Roma Wolves head coach Jimmy Douglas as the General Manager [41] For the majority of the season the club was plagued with injuries, suspensions, and a poor team chemistry which resulted in a struggle to clinch the final playoff berth, and ended in a failure by falling short by four points.

[43] The season marked an end to the club's golden era which began in the final years of the CNSL, and concluded in the infant stages of the CPSL.

During their rebuilding period Ianiero retired in 2004 after failing to qualify for the playoffs in two straight seasons, but managed a respectable run in the 2003 Open Canada Cup tournament by reaching the semi-finals before losing out to the Metro Lions by a score of 2–1.

After five straight seasons of failing to secure a postseason berth, St. Catharines appointed the services of James McGillivray as head coach.

The Wolves returned to prosperity by achieving a nine-game undefeated streak, and clinching the National Division title their first piece of silverware since 2001.

In 2012–13, following the controversy faced by the CSL over the Canadian Soccer Association decision to adopt the recommendations from the Rethink Management Report the CSA de-sanctioned the league putting the future of many of its clubs and operations in doubt.