St. Charles is an unincorporated community and census-designated place (CDP) in Lee County, South Carolina, United States.

It was first listed as a CDP prior to the 2020 census[3] with a population of 114.

[4] The CDP is in southern Lee County, at the junction of U.S. Route 401 and South Carolina Highway 154.

Note: the US Census treats Hispanic/Latino as an ethnic category.

This South Carolina state location article is a stub.