St. Charles College was a school in St. Charles, Missouri, established by the Methodist Episcopal Church in 1837.
John F. Fielding served as the first president until his death in 1842.
During the American Civil War, classes were suspended and the local militia commander, Arnold Krekel, used the school for a hospital and also a prison.
In 1891, the school admitted female students for the first time.
That building in turn burned down in 1922.