[4] St Cuthbert's Mission was founded in the late 1800s by Joseph Ferguson, who was also the village's first Kafotay (Chief in the Arawak language).

[2][4][5] In February 2011, St Cuthbert's suffered from a major flood, with levels of accumulated water reaching 311.3 millimetres.

The celebrations were attended by a number of senior government officials and thousands of visitors from Guyana as well as other countries.

[4] In August 1988, the leading Guyanese artist and native of St. Cuthbert's Mission, George Simon, founded a drawing and design workshop in the village.

The workshop fostered a number of Lokono artistic talents in the village who have since achieved artistic recognition in their own right, including Oswald ("Ossie") Hussein, Foster Simon, Roland Taylor, Telford Taylor and Lynus Clenkian.