It is part of the Roman Catholic Archdiocese of Miami and consists of 118 parishes, spanning Coral Springs in the north and Key West, Florida in the south.
In 1968 the Dominican Monastery in downtown Miami closed and the priests moved to St. Dominic, effectively creating its current priory.
Black Americans were struggling for their civil rights, the Vietnam War was in process, and Vatican II had just “opened (its) windows” to Christ.
On the church's exterior there are ten stained glass windows in the shape of arches depicting important themes in Catholicism.
The second and middle mosaic depicts Jesus "blessing and sending the 12 (Apostles) to announce the Good News" and St. Dominic welcoming the onlooker.
Both the stained glass windows and the arched mosaics were produced by the same artist, Father Domingo Iturgaiz from Navarre, Spain.
The church roof is in the shape of a triangular spire and its summit contains an iron cross that is illuminated at night.
Alongside the walls with the stained glass windows are the Stations of the Cross by Spanish artist Jose Luis Coomonte.