The perimeter of the western side of the site formed part of the Cottonera lines, a fortified wall built by the Knights of St John.

The extensive grounds between the bastion walls and the old hospital buildings would serve as ideal recreational areas and would also give the college enough space for expansion when needed.

[2] Thus, with an ideal site secured and the necessary financial backing guaranteed, a small group of men, among them senior notable members of the Maltese nobility, gathered in the Governor's Palace in Valletta on 18 January 1929 to sign a foundation deed of trust.

A successful fundraising campaign resulted in the laying of the foundation stone of the new block in 1967 by Sir Maurice Dorman, the last British Governor-General of Malta.

Classrooms were enlarged and the designs (by Old Edwardian Richard England) also ensured that the junior school building now had their own drama and music hall as well as an IT room.

Other well known alumni include architect Richard England, the late former Lord Chief Justice of England and Wales, Igor Judge, Baron Judge, former President of Malta Ugo Mifsud Bonnici, the late Chief Justice Emeritus Giuseppe Mifsud Bonnici, Archbishop of Malta Charles Scicluna.